Species Human Entrez 57805 | Human Mouse Ensembl ENSG00000158941 | |
Aliases CCAR2, DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC, cell cycle and apoptosis regulator 2 External IDs MGI: 2444228 HomoloGene: 10910 GeneCards: CCAR2 | ||
KIAA1967, also known as Deleted in Breast Cancer 1, is a protein which in humans is encoded by the KIAA1967 gene.
Function
Recent studies show that DBC1 is an inhibitor of the sirtuin-type deacetylase, SIRT1, which deacetylates histones and p53. DBC1 is likely to regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.
References
KIAA1967 Wikipedia(Text) CC BY-SA