Species Human Entrez 9682 | Human Mouse Ensembl ENSG00000066135 | |
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Aliases KDM4A, JHDM3A, JMJD2, JMJD2A, TDRD14A, lysine demethylase 4A External IDs MGI: 2446210 HomoloGene: 27780 GeneCards: KDM4A | ||
Lysine-specific demethylase 4A is an enzyme that in humans is encoded by the KDM4A gene.
Function
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone on histone H3 lysine 9 and 36 residues to the dimethylated form and lysine 9 dimethylated residues to monomethyl, and as a transcriptional repressor.
Alterations in this gene have been found associated with chromosomal instability that leads to cancer.(PMID 23871696)
References
KDM4A Wikipedia(Text) CC BY-SA