Joseph Adjignon Keke (born December 5, 1927) is a Beninese politician.
Keke was born on December 5, 1927 in Avrankou. He earned a degree in law and was Sourou-Migan Apithy's prime lieutenant. He was elected a deputy in 1959, representing the Parti Républicain Dahoméen, and became the party's vice president until 1960. He was appointed minister of justice in Hubert Maga's first administration, serving from November 1960 to 1963. He was deposed as a minister in the 1963 coup. With the creation of the Presidential Council in 1970, Apithy appointed Keke minister of economics and planning. He served in this role until 1973.
Keke practiced law in Cotonou during Mathieu Kérékou's military rule. In 1990, with the return to civilian politics, he made his political return as a party leader since Apithy died the previous year. He joined with Justin Ahomadégbé-Tomêtin to form the Rassemblement National pour la Democratie. Keke contested the presidential election in 1991, which he lost but he was elected to the Beninese National Assembly. Despite being Nicephore Soglo's choice as speaker, he did not attain that position.