Josefa is a given name. Notable people with the name include:
Infanta Francisca Josefa of Portugal (1699-1736), last of eight children of King Peter II of Portugal and his second wife Marie Sophie of Neuburg
Infanta Maria Josefa of Spain (1744-1801), Princess of Naples and Sicily
María Josefa García Granados (1796-1848), Guatemalan writer
María Josefa Lastiri (1792-1846), First Lady of the Federal Republic of Central America
María Josefa Pimentel, Duchess of Osuna (1752-1834), Spanish aristocrat
María Luisa Josefa (1866-1937), Mexican Roman Catholic nun
Josefa Acevedo de Gomez (1803-1861), Colombian novelist
Josefa Bayeu (18th century), wife of Francisco Goya
Josefa Berens-Totenohl (1891-1969), German writer
Josefa de Godoy di Bassano, 2nd Viscountess of Rocafuerte (1834-1882), Spanish-Italian aristocrat
Josefa de Óbidos (1630-1684), Spanish-Portuguese painter
Josefa de Tudó, 1st Countess of Castillo Fiel (1779-1869), mistress of Manuel de Godoy
Josefa Dimuri (21st century), Fijian politician
Josefa Idem (born 1964), West German-Italian sprint canoeist
Josefa Iloilo (born 1920), President of Fiji
Josefa Köster (born 1918), West German sprint canoeist
Josefa Llanes Escoda (circa 1898-1945), National Executive of the Girl Scouts of the Philippines
Josefa Martín Luengo (1944-2009), Spanish educator
Josefa Moe (1933-2006), American entertainer
Josefa Ordonez (1728-fl. 1792), Mexican actress and courtesan
Josefa Ortiz de Domínguez (1768-1829), supporter of the Mexican War of Independence
Josefa Rika (born 1987), Fijian cricketer
Josefa Vosanibola (21st century), Fijian politician