Jessel is a surname. Notable people with the surname include:
Sir Charles Jessel, (1860–1928), baronet, British barrister, magistrate and businessmanDavid Jessel, British journalistGeorge Jessel:George Jessel (actor) (1898–1981), American vaudevillianGeorge Jessel (jurist) (1824–1883), British juristHerbert Jessel, 1st Baron Jessel (1866–1950), British soldier and politicianLeon Jessel, German composerPatricia Jessel, actressStephen Jessel, British correspondentRay Jessel (1929—2015), American welsh composerThomas Jessell, scientistToby Jessel, British politician