Jessel is a surname. Notable people with the surname include:
Sir Charles Jessel, (1860–1928), baronet, British barrister, magistrate and businessman
David Jessel, British journalist
George Jessel:
George Jessel (actor) (1898–1981), American vaudevillian
George Jessel (jurist) (1824–1883), British jurist
Herbert Jessel, 1st Baron Jessel (1866–1950), British soldier and politician
Leon Jessel, German composer
Patricia Jessel, actress
Stephen Jessel, British correspondent
Ray Jessel (1929—2015), American welsh composer
Thomas Jessell, scientist
Toby Jessel, British politician
