Jerningham is a surname. Notable people with the surname include:
Jerningham Wakefield (1820–1879), the only son of Edward Gibbon Wakefield
Henry Jerningham (1512–1572), English courtier during the reigns of Henry VIII, Edward VI, Mary I and Elizabeth I
Henry Stafford-Jerningham, 9th Baron Stafford (1802–1884), British peer and politician
Hubert Jerningham, KCMG, DL (1842–1914), British Liberal Party politician and Governor of Trinidad and Tobago 1897–1900
