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Jerónimo Rodriguez de Espinosa (1562 in Valladolid–c. 1630 in Valencia) was a Spanish painter of the Renaissance period active in the region of Valencia.
He was born at Valladolid, where he received his initial training, and as an adult moved to the Valencian town of Cocentaina. There he married, in 1596, Aldonza Lied, by whom he fathered Jerónimo Jacinto de Espinosa, a painter of great reputation in the reign of Philip IV.
For the church of the town Espinosa painted, in 1600, pictures of St. Lorenzo and St. Hipdlito ; and the year following, St. Sebastian and St. Roque, of which he made an offering to the same edifice. In 1604-7 he executed, in conjunction with a certain Jayme Terol, a scholar of Fray Nicolas Borras, the pictures for the high altar of St. John Baptist's church, at the town of Muro. He died in Valencia.