Jeffers is a surname. Notable people with the surname include:
Audrey Jeffers (1898-1968), Trinidadian social worker and politician
Francis Jeffers, English football player
Henry W. Jeffers (1871-1953), American dairyman and politician
Lamar Jeffers (1888-1983), American politician
Maurice Jeffers, American basketball player
Oliver Jeffers, Irish illustrator
Othyus Jeffers (born 1985), American basketball player
Patrick Jeffers, American football player
Robinson Jeffers (1887-1962), American poet
Rusty Jeffers, American bodybuilder
Shane Jeffers, West Indies cricket player
Sue Jeffers, American restaurateur and politician
Susan Jeffers (1938-2012), American psychologist and author of self-help literature
William Nicholson Jeffers (1824-1883), American naval officer
W. W. Jeffers, Canadian baseball umpire
