Jeffers is a surname. Notable people with the surname include:
Audrey Jeffers (1898-1968), Trinidadian social worker and politicianFrancis Jeffers, English football playerHenry W. Jeffers (1871-1953), American dairyman and politicianLamar Jeffers (1888-1983), American politicianMaurice Jeffers, American basketball playerOliver Jeffers, Irish illustratorOthyus Jeffers (born 1985), American basketball playerPatrick Jeffers, American football playerRobinson Jeffers (1887-1962), American poetRusty Jeffers, American bodybuilderShane Jeffers, West Indies cricket playerSue Jeffers, American restaurateur and politicianSusan Jeffers (1938-2012), American psychologist and author of self-help literatureWilliam Nicholson Jeffers (1824-1883), American naval officerW. W. Jeffers, Canadian baseball umpire