Jean de Luxembourg or John of Luxembourg may refer to:
John of Bohemia (1296-1346), King of Bohemia and Count of Luxembourg.
John I, Lord of Ligny (1313-1364) , Count of Ligny
John of Luxembourg, Lord of Beauvoir (c. 1370 – 1397), Lord of Beauvoir
John II of Luxembourg, Count of Ligny (1392–1441)
John of Luxembourg (died 1476), Count of Soissons
Jean de Luxembourg (1400-1466), Admiral of Flanders
John III, Count of Ligny (died 1576)
Jean, Grand Duke of Luxembourg (born 1921)
Prince Jean of Luxembourg (born 1957)