Jean-Sébastien is a French masculine given name. Notable people with the name include:
Jean-Sébastien Aubin (born 1977), Canadian professional ice hockey goaltenderJean-Sébastien Fecteau (born 1975), Canadian figure skaterJean-Sébastien Giguère (born 1977), retired French-Canadian professional ice hockey playerJean-Sébastien Jaurès (born 1977), French football playerJean-Sébastien Lavoie (born 1978), French Canadian singerJean-Sébastien Vialatte (born 1951), member of the National Assembly of France