Jean-François is a French given name.
Notable people bearing the given name include:
Jean-François Champollion (1790–1832), French EgyptologistJean-François Dagenais (born 1975), Canadian music producer and guitarist of death metal band KataklysmJean-François David (born 1982), Canadian ice hockey playerJean-François de La Harpe (1739–1803), French criticJean-François Marceau (born 1976), Canadian judokaJean-François Marmontel (1723–1799), French historian and writerJean-François Martial (1891-1977), Belgian actorJean-François Millet (1814–1875), French painterJean-François Papillon (died 1805), Haitian revolutionaryJean-François Racine (born 1982), Canadian ice hockey playerJean-François Rewbell (1747–1807), French politicianJean-François Séguier (1703–1784), French astronomer and botanist