Jayewardene or Jayawardene is a Sinhalese surname. Notable people with the surname include:
A. S. Jayawardene (born 1936), Sri Lankan economist and civil servantAsoka Jayawardena, Sri Lankan army officerDilan Jayawardane, Sri Lankan American engineerDommie Jayawardena (1927–1979), Sri Lankan actor and singerEugene Wilfred Jayewardene (1874–1932), Ceylonese lawyer and judgeHarry Jayawardena (born 1942), Sri Lankan businessmanHector Alfred Jayewardene (1870–1913), Ceylonese lawyer and politicianHector Wilfred Jayewardene (1916–1990), Sri Lankan lawyerJ. R. Jayewardene (1906–1996), Sri Lankan politicianJayalath Jayawardena (1953–2013), Sri Lankan physician and politicianJohn Adrian St. Valentine Jayewardene (1877–1927), Ceylonese lawyer and judgeKumari Jayawardena (born 1931), Sri Lankan academicLal Jayawardena (1935–2004), Sri Lankan economist and diplomatLucky Jayawardena, Sri Lankan politicianMahela Jayawardene (born 1977), Sri Lankan cricketerN. U. Jayawardena (1908–2002), Sri Lankan economist and bankerNalin Jayawardena (born 1957), Sri Lankan singer and vocalistNuwan Jayawardene (born 1978), Sri Lankan cricketerPrasad Jayawardene (born 1980), Sri Lankan cricketerPrasanna Jayawardene (born 1979), Sri Lankan cricketerRanil Jayawardena (born 1986), British Conservative Party politician, Member of Parliament (MP) for North East Hampshire since May 2015Sahan Jayawardene (born 1990), Sri Lankan cricketerSarath Jayawardene (born 1969), Sri Lankan cricketerTheodore Godfrey Wijesinghe Jayewardene (1872–1945), Ceylonese engineer and politician