Jayewardene or Jayawardene is a Sinhalese surname. Notable people with the surname include:
A. S. Jayawardene (born 1936), Sri Lankan economist and civil servant
Asoka Jayawardena, Sri Lankan army officer
Dilan Jayawardane, Sri Lankan American engineer
Dommie Jayawardena (1927–1979), Sri Lankan actor and singer
Eugene Wilfred Jayewardene (1874–1932), Ceylonese lawyer and judge
Harry Jayawardena (born 1942), Sri Lankan businessman
Hector Alfred Jayewardene (1870–1913), Ceylonese lawyer and politician
Hector Wilfred Jayewardene (1916–1990), Sri Lankan lawyer
J. R. Jayewardene (1906–1996), Sri Lankan politician
Jayalath Jayawardena (1953–2013), Sri Lankan physician and politician
John Adrian St. Valentine Jayewardene (1877–1927), Ceylonese lawyer and judge
Kumari Jayawardena (born 1931), Sri Lankan academic
Lal Jayawardena (1935–2004), Sri Lankan economist and diplomat
Lucky Jayawardena, Sri Lankan politician
Mahela Jayawardene (born 1977), Sri Lankan cricketer
N. U. Jayawardena (1908–2002), Sri Lankan economist and banker
Nalin Jayawardena (born 1957), Sri Lankan singer and vocalist
Nuwan Jayawardene (born 1978), Sri Lankan cricketer
Prasad Jayawardene (born 1980), Sri Lankan cricketer
Prasanna Jayawardene (born 1979), Sri Lankan cricketer
Ranil Jayawardena (born 1986), British Conservative Party politician, Member of Parliament (MP) for North East Hampshire since May 2015
Sahan Jayawardene (born 1990), Sri Lankan cricketer
Sarath Jayawardene (born 1969), Sri Lankan cricketer
Theodore Godfrey Wijesinghe Jayewardene (1872–1945), Ceylonese engineer and politician
