Jayasinghe is a Sinhalese surname. Notable people with the surname include:
Susanthika Jayasinghe (born 1975), Sri Lankan athlete
Chinthaka Jayasinghe (born 1978), Sri Lankan cricketer
Dilan Jayasingha (born 1987), Sri Lankan American hip-hop artist
Stanley Jayasinghe (born 1931), former Sri Lankan cricketer
Lalith Jayasinghe (1974 - 2008), lieutenant colonel in the Sri Lanka Army
Rohan Jayasinghe (born 1956), brigadier in the Sri Lanka Army
Sunil Jayasinghe (born 1955), former Sri Lankan cricketer
Chandrani Bandara Jayasinghe (born 1962), member of the Parliament of Sri Lanka
Romesh Jayasinghe (born 1981), Sri Lankan cricketer
G. R. Jayasinghe, Brigadier in the Sri Lanka Army
N. D. N. P. Jayasinghe, former member of the Parliament of Sri Lanka
