Jayasinghe is a Sinhalese surname. Notable people with the surname include:
Susanthika Jayasinghe (born 1975), Sri Lankan athleteChinthaka Jayasinghe (born 1978), Sri Lankan cricketerDilan Jayasingha (born 1987), Sri Lankan American hip-hop artistStanley Jayasinghe (born 1931), former Sri Lankan cricketerLalith Jayasinghe (1974 - 2008), lieutenant colonel in the Sri Lanka ArmyRohan Jayasinghe (born 1956), brigadier in the Sri Lanka ArmySunil Jayasinghe (born 1955), former Sri Lankan cricketerChandrani Bandara Jayasinghe (born 1962), member of the Parliament of Sri LankaRomesh Jayasinghe (born 1981), Sri Lankan cricketerG. R. Jayasinghe, Brigadier in the Sri Lanka ArmyN. D. N. P. Jayasinghe, former member of the Parliament of Sri Lanka