Jayaratne is a Sinhalese surname. Notable people with the surname include:
Ajit Jayaratne, Sri Lankan businessmanAnuradha Jayaratne (born 1985), Sri Lankan politicianD. M. Jayaratne (born 1931), Sri Lankan politicianIshan Jayaratne (born 1989), Sri Lankan cricketerJayantha de S. Jayaratne, Sri Lankan army officerJerome Jayaratne, Sri Lankan cricketer and coachOsmund Jayaratne (died 2006), Sri Lankan academic and politicianPiyankara Jayaratne (born 1964), Sri Lankan politicianT. M. Jayaratne (born 1944), Sri Lankan singerTilak Jayaratne (1943–2012), Sri Lankan broadcaster