Janse van Rensburg is a South African surname. Notable people sharing this surname include:
Brent Janse van Rensburg (born 1980), South African rugby union coach
Hector Janse van Rensburg (born 1993), aka Shitty_Watercolour, British painter
Jacques Janse van Rensburg (born 1987), South African cyclist
JC Janse van Rensburg (born 1986), South African rugby union footballer
Jono Janse van Rensburg (born 1989), South African rugby union player
Jurinus Janse van Rensburg, South African military commander
Lang Hans Janse van Rensburg (1779–1836), South African leader
Nico Janse van Rensburg (born 1994), South African rugby union player
Reinardt Janse van Rensburg (born 1989), South African road bicycle racer
Rohan Janse van Rensburg (born 1994), South African rugby union player
Rhyno Janse van Rensburg (born 1991), South African cricketer
Siener Janse van Rensburg (1864–1926), South African prophet
Willem Cornelis Janse van Rensburg (1818–1865), South African politician
William GL Janse van Rensburg (1939–2008), mayor of Johannesburg, South Africa
