James Irvine (1793–1835) was an educator and Presbyterian minister who served as the second president of Ohio University, located in Athens, Ohio, from 1822 to 1824.
Irvine, a native of Washington County, New York, graduated from Union College, and was hired as a professor of mathematics at Ohio University in 1821. He became president of the university in 1822, but served only a year before taking a leave of absence on account of poor health. Irvine never returned from his leave and resigned in 1824. He was pastor at West Hebron, New York, 1824-31, and of the Second Presbyterian Church of New York City, 1831-35. He died in New York City, November 25, 1835.