James Clarke may refer to:
James Clarke (died 1599), English MP for Leicester
James Clarke (died 1612), English MP for Mitchell
James Clarke (died 1621), English MP for Taunton
James Clarke (Iowa politician) (1812–1850), American politician and Governor of Iowa Territory
James M. Clarke (1917–1999), American politician and farmer from North Carolina
James Paul Clarke (1854–1916), American politician from Arkansas
Jim Clarke (Northern Ireland politician), Unionist politician in Northern Ireland
James Clarke (composer) (born 1957), British composer
James P. Clarke (composer) (1807/8–1877), Canadian composer
James Clarke (athlete) (1874–1929), Irish Olympic tug of war competitor
James Clarke (cricketer) (born 1979), former English cricketer
James Kenelm Clarke (born 1941), British film director and producer
Jim Clarke (ice hockey) (born 1954), Canadian professional ice hockey defenceman
James Clarke (1930s footballer), English footballer
James Clarke (footballer, born 1989), English footballer
James Clarke (author) (born 1972), cinema author
James Clarke (VC) (1894–1947), English World War I soldier and recipient of the Victoria Cross
James Fernandez Clarke (1812–1876), English surgeon and medical writer
James Freeman Clarke (1810–1888), American preacher and author
James Stanier Clarke (1766–1834), English cleric, author and librarian to the Prince of Wales
James Clarke, a fictional character in Stingers, a story by Graham Downs
