Jaffee is the surname of:
Al Jaffee (born 1921), American cartoonist best known for his work for Mad magazineEllen Jaffee, member of the New York State AssemblyIrving Jaffee (1906-1981), American speed skater and double gold medalist at the 1932 Winter OlympicsRami Jaffee (born 1969), American keyboardist of the rock band The WallflowersSusan Nirah Jaffee, American screenwriter and television producer