Jaffe is a surname. It may also be spelled Jaffé:
Aaron Jaffe. American politician
Andrew Jaffe, journalist
Aniela Jaffé, (February 20, 1903 – October 30, 1991), a Swiss analyst who for many years was a co-worker of Carl Jung
Arthur Jaffe, mathematical physicist
Billy Jaffe (born 1969), color analyst for the New York Islanders on MSG Plus
Charles Jaffe (circa 1879 – 12 July 1941), Belarusian-American chess master
Daniel Jaffe, American astronomer
David Jaffe, video game designer and director
David A. Jaffe, composer of contemporary classical and electronic/computer music
Elaine Jaffe, American pathologist, expert in hematopathology
Eliezer Jaffe, professor
Frederick S. Jaffe, (1925–1978), vice president of Planned Parenthood and founder of the Guttmacher Institute
Jerome H. Jaffe, psychiatrist
Marielle Jaffe (born 1989), an American model and actress
Michael Jaffé (3 June 1923 – 13 July 1997), a British art historian and curator
Moe Jaffe (1901–1972), American songwriter and band leader
Naomi Jaffe, activist
Nicole Jaffe, American actress
Norman Jaffe, American architect
Sir Otto Jaffe (born 1846), prominent Jewish businessman, High Sheriff and Lord Mayor of Belfast
Peter Jaffe (born 1913), British sailor and Olympic silver medalist
Philipp Jaffé (February 17, 1819 – April 3, 1870), a German historian and philologist
Philip Jaffe (1895–1980), left-wing American editor and writer.
Robert Jaffe, physicist and professor
Robert Jaffe (stockbroker) (born 1944), associate of Bernard Madoff
Rona Jaffe (born 1932), U.S. author
Sam Jaffe (actor) (1891–1984), American film actor
Sam Jaffe (producer) (1901–2000), American film producer later in England
Sarah Jaffe (born 1986), American singer-songwriter
Scott Jaffe (born 1969), American freestyle swimmer
Stanley R. Jaffe (born 1940), American film producer
Stephen Jaffe, American composer
Taliesin Jaffe, (born 1977), American voice actor
Theodor Julius Jaffé (August 17, 1823 – April 11, 1898), a German actor
Werner Jaffé (October 27, 1914 – May 3, 2009), a German chemist and university professor
William Jaffé (1898 – 1980), an American economist and historian of economic thought