Jacquinot is a French surname. Notable people with the surname include:
Charles Jacquinot, French admiral and Antarctic explorer
Honoré Jacquinot (1815–1887), French surgeon and zoologist, brother of Charles-Hector
Louis Jacquinot (1898–1993), French lawyer and politician, several times minister
Robert Jacquinot (1893–1980), French road racing cyclist
Robert Jacquinot de Besange (1878-1946), French Jesuit