JWH 424

JWH-424 is a drug from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors, but with moderate selectivity for CB₂, having a K_i of 5.44nM at CB₂ vs 20.9nM at CB₁. The heavier 8-iodo analogue is even more CB₂ selective, with its 2-methyl derivative having 40x selectivity for CB₂. However the 1-propyl homologues in this series showed much lower affinity at both receptors, reflecting a generally reduced affinity for the 8-substituted naphthoylindoles overall.