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Istanbul Girls' High School (Turkish: İstanbul Kız Lisesi) was the first girls school established by the state in Ottoman Turkey.
Inaugurated on March 21, 1850, by Sadrazam Mustafa Reshid Pasha, one of the architects of the Tanzimat reforms, in a building donated by Bezm-i Alem Valide Sultan, mother of Abdulmecid I. At the beginning, it was a secondary school (Turkish: rüşdiye). The school took the name İnas İdadisi (Girls Lycee) in 1911, and later İnas Sultanisi (Imperial High School for Girls).
During most of the republican period in Turkey, the school was known under the name İstanbul Kız Lisesi, but always related to its founding mother Bezm-i Alem, whose name it carried officially as Bezm-i Alem Sultanisi for about a decade until 1924, when it was renamed.
The school could not be spared from a spree of closing (or turning into a mixed gender school) what other girls-only schools also experienced in Turkey in the early 1980s. It did not receive more students since 1984, giving its final graduates in 1988, and disappearing. At its closure, its building made place to home Cağaloğlu Anatolian High School.