In probability theory, Isserlis’ theorem or Wick’s theorem is a formula that allows one to compute higher-order moments of the multivariate normal distribution in terms of its covariance matrix. It is named after Leon Isserlis.
This theorem is particularly important in particle physics, where it is known as Wick's theorem after the work of Wick (1950). Other applications include the analysis of portfolio returns, quantum field theory and generation of colored noise.
If (X1, …, X2n) is a zero mean multivariate normal random vector, then
  
    
      
        
          
            
              
              
                E
                
                [
                
                
                  X
                  
                    1
                  
                
                
                  X
                  
                    2
                  
                
                ⋯
                
                  X
                  
                    2
                    n
                  
                
                
                ]
                =
                ∑
                ∏
                E
                
                [
                
                
                  X
                  
                    i
                  
                
                
                  X
                  
                    j
                  
                
                
                ]
                ,
              
            
            
              
              
                E
                
                [
                
                
                  X
                  
                    1
                  
                
                
                  X
                  
                    2
                  
                
                ⋯
                
                  X
                  
                    2
                    n
                    −
                    1
                  
                
                
                ]
                =
                0
                ,
              
            
          
        
      
    
    
  
where the notation ∑ ∏ means summing over all distinct ways of partitioning X1, …, X2n into pairs Xi,Xj and each summand is the product of the n pairs. This yields 
  
    
      
        (
        2
        n
        )
        !
        
          /
        
        (
        
          2
          
            n
          
        
        n
        !
        )
      
    
    
   terms in the sum. For example, for fourth order moments (four variables) there are three terms. For sixth-order moments there are 3 × 5 = 15 terms, and for eighth-order moments there are 3 × 5 × 7 = 105 terms (as you can check in the examples below).
In his original paper, Leon Isserlis proves this theorem by mathematical induction, generalizing the formula for the fourth-order moments, which takes the appearance
  
    
      
        E
        
        [
        
        
          X
          
            1
          
        
        
          X
          
            2
          
        
        
          X
          
            3
          
        
        
          X
          
            4
          
        
        
        ]
        =
        E
        
        [
        
          X
          
            1
          
        
        
          X
          
            2
          
        
        ]
        
        E
        
        [
        
          X
          
            3
          
        
        
          X
          
            4
          
        
        ]
        +
        E
        
        [
        
          X
          
            1
          
        
        
          X
          
            3
          
        
        ]
        
        E
        
        [
        
          X
          
            2
          
        
        
          X
          
            4
          
        
        ]
        +
        E
        
        [
        
          X
          
            1
          
        
        
          X
          
            4
          
        
        ]
        
        E
        
        [
        
          X
          
            2
          
        
        
          X
          
            3
          
        
        ]
        .
      
    
    
  
For sixth-order moments, Isserlis' theorem is:
  
    
      
        
          
            
              
              
                E
                
                [
                
                  X
                  
                    1
                  
                
                
                  X
                  
                    2
                  
                
                
                  X
                  
                    3
                  
                
                
                  X
                  
                    4
                  
                
                
                  X
                  
                    5
                  
                
                
                  X
                  
                    6
                  
                
                ]
              
            
            
              
                =
                
                
              
              
                E
                
                [
                
                  X
                  
                    1
                  
                
                
                  X
                  
                    2
                  
                
                ]
                E
                
                [
                
                  X
                  
                    3
                  
                
                
                  X
                  
                    4
                  
                
                ]
                E
                
                [
                
                  X
                  
                    5
                  
                
                
                  X
                  
                    6
                  
                
                ]
                +
                E
                
                [
                
                  X
                  
                    1
                  
                
                
                  X
                  
                    2
                  
                
                ]
                E
                
                [
                
                  X
                  
                    3
                  
                
                
                  X
                  
                    5
                  
                
                ]
                E
                
                [
                
                  X
                  
                    4
                  
                
                
                  X
                  
                    6
                  
                
                ]
                +
                E
                
                [
                
                  X
                  
                    1
                  
                
                
                  X
                  
                    2
                  
                
                ]
                E
                
                [
                
                  X
                  
                    3
                  
                
                
                  X
                  
                    6
                  
                
                ]
                E
                
                [
                
                  X
                  
                    4
                  
                
                
                  X
                  
                    5
                  
                
                ]
              
            
            
              
              
                
                
                
                +
                E
                
                [
                
                  X
                  
                    1
                  
                
                
                  X
                  
                    3
                  
                
                ]
                E
                
                [
                
                  X
                  
                    2
                  
                
                
                  X
                  
                    4
                  
                
                ]
                E
                
                [
                
                  X
                  
                    5
                  
                
                
                  X
                  
                    6
                  
                
                ]
                +
                E
                
                [
                
                  X
                  
                    1
                  
                
                
                  X
                  
                    3
                  
                
                ]
                E
                
                [
                
                  X
                  
                    2
                  
                
                
                  X
                  
                    5
                  
                
                ]
                E
                
                [
                
                  X
                  
                    4
                  
                
                
                  X
                  
                    6
                  
                
                ]
                +
                E
                
                [
                
                  X
                  
                    1
                  
                
                
                  X
                  
                    3
                  
                
                ]
                E
                
                [
                
                  X
                  
                    2
                  
                
                
                  X
                  
                    6
                  
                
                ]
                E
                
                [
                
                  X
                  
                    4
                  
                
                
                  X
                  
                    5
                  
                
                ]
              
            
            
              
              
                
                
                
                +
                E
                
                [
                
                  X
                  
                    1
                  
                
                
                  X
                  
                    4
                  
                
                ]
                E
                
                [
                
                  X
                  
                    2
                  
                
                
                  X
                  
                    3
                  
                
                ]
                E
                
                [
                
                  X
                  
                    5
                  
                
                
                  X
                  
                    6
                  
                
                ]
                +
                E
                
                [
                
                  X
                  
                    1
                  
                
                
                  X
                  
                    4
                  
                
                ]
                E
                
                [
                
                  X
                  
                    2
                  
                
                
                  X
                  
                    5
                  
                
                ]
                E
                
                [
                
                  X
                  
                    3
                  
                
                
                  X
                  
                    6
                  
                
                ]
                +
                E
                
                [
                
                  X
                  
                    1
                  
                
                
                  X
                  
                    4
                  
                
                ]
                E
                
                [
                
                  X
                  
                    2
                  
                
                
                  X
                  
                    6
                  
                
                ]
                E
                
                [
                
                  X
                  
                    3
                  
                
                
                  X
                  
                    5
                  
                
                ]
              
            
            
              
              
                
                
                
                +
                E
                
                [
                
                  X
                  
                    1
                  
                
                
                  X
                  
                    5
                  
                
                ]
                E
                
                [
                
                  X
                  
                    2
                  
                
                
                  X
                  
                    3
                  
                
                ]
                E
                
                [
                
                  X
                  
                    4
                  
                
                
                  X
                  
                    6
                  
                
                ]
                +
                E
                
                [
                
                  X
                  
                    1
                  
                
                
                  X
                  
                    5
                  
                
                ]
                E
                
                [
                
                  X
                  
                    2
                  
                
                
                  X
                  
                    4
                  
                
                ]
                E
                
                [
                
                  X
                  
                    3
                  
                
                
                  X
                  
                    6
                  
                
                ]
                +
                E
                
                [
                
                  X
                  
                    1
                  
                
                
                  X
                  
                    5
                  
                
                ]
                E
                
                [
                
                  X
                  
                    2
                  
                
                
                  X
                  
                    6
                  
                
                ]
                E
                
                [
                
                  X
                  
                    3
                  
                
                
                  X
                  
                    4
                  
                
                ]
              
            
            
              
              
                
                
                
                +
                E
                
                [
                
                  X
                  
                    1
                  
                
                
                  X
                  
                    6
                  
                
                ]
                E
                
                [
                
                  X
                  
                    2
                  
                
                
                  X
                  
                    3
                  
                
                ]
                E
                
                [
                
                  X
                  
                    4
                  
                
                
                  X
                  
                    5
                  
                
                ]
                +
                E
                
                [
                
                  X
                  
                    1
                  
                
                
                  X
                  
                    6
                  
                
                ]
                E
                
                [
                
                  X
                  
                    2
                  
                
                
                  X
                  
                    4
                  
                
                ]
                E
                
                [
                
                  X
                  
                    3
                  
                
                
                  X
                  
                    5
                  
                
                ]
                +
                E
                
                [
                
                  X
                  
                    1
                  
                
                
                  X
                  
                    6
                  
                
                ]
                E
                
                [
                
                  X
                  
                    2
                  
                
                
                  X
                  
                    5
                  
                
                ]
                E
                
                [
                
                  X
                  
                    3
                  
                
                
                  X
                  
                    4
                  
                
                ]
                .