Issac is both a given name and surname. Notable people with the name include:
Given name
Issac Blakeney (born 1992), American football player
Issac Booth (born 1971), American football player
Issac Delgado (born 1962), Cuban musician, salsa and timba performer
Issac Honey (born 1993), Ghanaian footballer
Issac Koga (1899–1982), Japanese electronics engineer
Issac Luke (born 1987), New Zealand rugby league footballer
Surname
Rod Issac (born 1989), American football cornerback
