Isobel is a feminine given name. People named Isobel include:
Isobel of Huntingdon (1199-1251), Scottish royalty
Isobel Baillie (1895-1983), Scottish operatic soprano
Isobel Barnett (1918-1980), British radio and television personality
Isobel Buchanan (born 1954), Scottish operatic soprano
Isobel Campbell (born 1976), Scottish singer, formerly with Belle and Sebastian
Isobel Gowdie, Scottish woman who was tried for witchcraft in 1662
Isobel Elsom (1893-1981), English actress
Isobel Joyce (born 1983), Irish cricketer
Isobel Miller Kuhn (1901-1957), Canadian missionary
Isobel Lennart (1915-1971), American screenwriter and playwright
Isobel Redmond (born 1953), Australian politician
Isobel "Izzie" Stevens, a fictional character from the American medical drama Grey's Anatomy
Isobel Crawley, a fictional character from British period drama Downton Abbey
