Isham is a surname. Notable people with the surname include:
Ashley Isham (Eshamuddin Ismail)Sir Charles Isham, 10th Baronet (1819 - 1903)Christopher Isham, theoretical physicist (b. 1944)Edmund Isham (1744?–1817), an academic administrator at the University of OxfordSir Edmund Isham, 6th Baronet (1690-1772)Elizabeth Isham (c.1608-1654), writerEuseby Isham, Rector of Lincoln College, OxfordSir Gyles Isham, 12th Baronet (1903-1976)Heyward Isham (1926 - 2009)Isham Baronets of Lamport Hall in the County of NorthamptonshireJohn Isham (disambiguation)Sir John Isham, 1st Baronet (1582-1651)John William Isham (b. 1866), an American vaudeville impresario who was known for his Octoroons showSir Justinian Isham, 2nd Baronet (1610 – 1675)Sir Justinian Isham, 4th Baronet (1658-1730)Sir Justinian Isham, 5th Baronet (1687-1737)Sir Justinian Isham, 7th Baronet (1740-1818)Mark Isham (b. 1951)Norman Isham (1864-1943)Samuel Isham (1855–1914), painterSir Thomas Isham, 3rd Baronet (1656-1681)Wayne Isham (b. 1958), video directorWillard W. Isham (1820-1876), American politicianZacheus Isham (1651–1705), clergyman and religious author