Isham is a surname. Notable people with the surname include:
Ashley Isham (Eshamuddin Ismail)
Sir Charles Isham, 10th Baronet (1819 - 1903)
Christopher Isham, theoretical physicist (b. 1944)
Edmund Isham (1744?–1817), an academic administrator at the University of Oxford
Sir Edmund Isham, 6th Baronet (1690-1772)
Elizabeth Isham (c.1608-1654), writer
Euseby Isham, Rector of Lincoln College, Oxford
Sir Gyles Isham, 12th Baronet (1903-1976)
Heyward Isham (1926 - 2009)
Isham Baronets of Lamport Hall in the County of Northamptonshire
John Isham (disambiguation)
Sir John Isham, 1st Baronet (1582-1651)
John William Isham (b. 1866), an American vaudeville impresario who was known for his Octoroons show
Sir Justinian Isham, 2nd Baronet (1610 – 1675)
Sir Justinian Isham, 4th Baronet (1658-1730)
Sir Justinian Isham, 5th Baronet (1687-1737)
Sir Justinian Isham, 7th Baronet (1740-1818)
Mark Isham (b. 1951)
Norman Isham (1864-1943)
Samuel Isham (1855–1914), painter
Sir Thomas Isham, 3rd Baronet (1656-1681)
Wayne Isham (b. 1958), video director
Willard W. Isham (1820-1876), American politician
Zacheus Isham (1651–1705), clergyman and religious author
