Isaacson is a surname meaning "son of Isaac", the Biblical figure.
People with the surname Isaacson include:
Doug Isaacson (born 1957), American politician
Jacob Isaacson (1911–1980), American composer and musician
James Isaacson (born 1980), English rugby union football player
Megan Isaacson, American gospel singer
Peter Isaacson (born 1920), English-born Australian newspaper publisher and military pilot
Thorpe B. Isaacson (1898–1970), American leader in The Church of Jesus Christ of Latter-day Saints
Walter Isaacson (born 1952), American author, columnist and CEO