Irby is a surname. Notable people with the surname include:
Anthony Irby (died 1625), English Master of Chancery, Recorder and MP of Boston
Anthony Irby (1577–1610), English politician
Anthony Irby (1605–1682), English Member of Parliament for Boston
Charles Irby, software architect
Charles Leonard Irby (1789-1845), explorer and writer, son of Frederick Irby, 2nd Baron Boston
Frederick Paul Irby (1779–1844), Royal Navy officer and son of Frederick Irby, 2nd Baron Boston
John L M Irby (1854–1900), US Senator representing South Carolina (1891–1897)
John R. Irby, editor of the Bismarck Tribune
Joyce Irby, bassist and co-lead vocalist of Klymaxx
Lee Irby (born 1963), American novelist and historian
Leonard Howard Loyd Irby Ornithologist
Kenneth Irby (born 1936), American poet
Michael Irby (born 1972), American film and television actor
Paulina Irby, educator and heroine
Sherman Irby, jazz alto saxophonist
