Symbol IT OPM superfamily 465 | Pfam clan CL0182 OPM protein 4r1i | |
The ion transporter (IT) superfamily is a superfamily of secondary carriers transport proteins specific for cationic and anionic compounds. Families belonging to the IT superfamily have been characterized base upon (1) the known substrates transported, (2) the modes of transport and energy coupling mechanisms used, (3) the family sizes (in numbers of sequenced protein members in the current NCBI database), (4) the organismal distributions of the members of each family, (5) the size ranges of the constituent proteins, (6) the predicted topologies of these proteins, and (7) the occurrence of non-homologous auxiliary proteins that may either facilitate or be required for transport.
Families
As of early 2016, the currently recognized and functionally defined families that make up the IT superfamily include: