Species Human Entrez 11009 | Human Mouse Ensembl ENSG00000162892 | |
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Aliases IL24, C49A, FISP, IL10B, MDA7, MOB5, ST16, IL-24, interleukin 24 External IDs OMIM: 604136 MGI: 2135548 HomoloGene: 4991 GeneCards: IL24 | ||
Gene music using protein sequence of il24 interleukin 24
Interleukin 24 (IL-24) is a protein that in humans is encoded by the IL24 gene.
IL-24 is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control in cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3. This cytokine is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, arthritis, psoriasis and cancer. Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24. The gene for IL-24 is located on chromosome 1 in humans.