Species Human Entrez 3590 | Human Mouse Ensembl ENSG00000137070 | |
Aliases IL11RA, CRSDA, Interleukin 11 receptor alpha subunit, interleukin 11 receptor subunit alpha External IDs MGI: 3780172 HomoloGene: 88705 GeneCards: IL11RA |
Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene.
Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.
References
Interleukin 11 receptor alpha subunit Wikipedia(Text) CC BY-SA