Trisha Shetty (Editor)

Integrated stress response

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Integrated Stress Response (ISR) is a cellular stress response common to all eukaryotes. ISR is a common denominator of different types of cellular stresses resulting in activation of at least one of the eIF-2 alpha (EIF2S1).

ISR results in the:

  • Down regulation of the general protein synthesis (CAP-dependent)
  • Up regulation of translation and expression of certain transcription factors, e.g. Activating Transcription Factor 4 (ATF4)

    • See also endoplasmic reticulum stress and the unfolded protein response.

    References

    Integrated stress response Wikipedia
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