Integral monotopic protein

Updated on Oct 12, 2024

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Integral monotopic proteins, are permanently attached to the membrane from one side.

Three-dimensional structures of the following integral monotopic proteins have been determined:

prostaglandin H2 syntheses 1 and 2 (cyclooxygenases)

lanosterol synthase and squalene-hopene cyclase

microsomal prostaglandin E synthase

carnitine O-palmitoyltransferase 2

There are also structures of integral monotopic domains of transmembrane proteins:

monoamine oxidases A and B

fatty acid amide hydrolase

mammalian cytochrome P450 oxidases

corticosteroid 11-beta-dehydrogenases

References

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