Indole 3 acetaldehyde reductase (NADPH)

In enzymology, an indole-3-acetaldehyde reductase (NADPH) (EC 1.1.1.191) is an enzyme that catalyzes the chemical reaction

(indol-3-yl)ethanol + NADP⁺ ⇌ (indol-3-yl)acetaldehyde + NADPH + H⁺

Thus, the two substrates of this enzyme are (indol-3-yl)ethanol and NADP⁺, whereas its 3 products are (indol-3-yl)acetaldehyde, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (indol-3-yl)ethanol:NADP⁺ oxidoreductase. Other names in common use include indoleacetaldehyde (reduced nicotinamide adenine dinucleotide, phosphate) reductase, indole-3-acetaldehyde reductase (NADPH), and indole-3-ethanol:NADP⁺ oxidoreductase. This enzyme participates in tryptophan metabolism.