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The Index of Sphericity (
  
    
      
        
The values used for finding the Index of Sphericity are the perimeter and the area of an irregular shape measured on a two-dimensional plane. The Index of Sphericity (
  
    
      
        
  
    
      
        
  
    
      
        
If the shape is irregular then the two formulas will provide different results. Thus, the average between the two results will be the mean diameter (
  
    
      
        
  
    
      
        
However, as a first reference point, the ratio between the circle perimeter (
  
    
      
        
  
    
      
        
Next, the same steps have been applied for the ratio (
  
    
      
        
  
    
      
        
The distance from the ideal proportions are quantified through the Index of Sphericity (
  
    
      
        
  
    
      
        
Thus, 
  
    
      
        
First use
The first application of this method was the quantification of islet sphericity throughout the human pancreas, by using morphometric measurements from histological slides.
