EC number 3.5.2.7 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9024-91-3 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, an imidazolonepropionase (EC 3.5.2.7) is an enzyme that catalyzes the chemical reaction
(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2OThus, the two substrates of this enzyme are (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate and H2O, whereas its two products are N-formimidoyl-L-glutamate and H+.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate amidohydrolase. Other names in common use include 4(5)-imidazolone-5(4)-propionic acid hydrolase, and imidazolone propionic acid hydrolase. This enzyme participates in histidine metabolism.
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 2BB0, 2G3F, 2GOK, 2OOF, 2PUZ, and 2Q09.