EC number 3.4.24.13 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 72231-73-3 BRENDA BRENDA entry KEGG KEGG entry | |
IgA-specific metalloendopeptidase (EC 3.4.24.13, immunoglobulin A1 proteinase, IgA protease, IgA1-specific proteinase, IgA1 protease, IgA1 proteinase) is an enzyme. This enzyme catalyses the following chemical reaction
Cleavage of Pro-Thr bond in the hinge region of the heavy chain of human immunoglobulin AThis enzyme is present in several pathogenic species of Streptococcus.
Other species, for instance bacteria that cause meningitis, gonorrhea, some cases of pneumonia, sinusitis and ear infections also produce an enzyme that cleaves IgA, but this is a serine protease and is metal-independent.
References
IgA-specific metalloendopeptidase Wikipedia(Text) CC BY-SA