Icosanoyl CoA synthase

In enzymology, an icosanoyl-CoA synthase (EC 2.3.1.119) is an enzyme that catalyzes the chemical reaction

The 5 substrates of this enzyme are stearoyl-CoA, malonyl-CoA, NADH, NADPH, and H⁺, whereas its 6 products are icosanoyl-CoA, CO₂, CoA, NAD⁺, NADP⁺, and H₂O.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is stearoyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing). Other names in common use include acyl-CoA elongase, C18-CoA elongase, and stearoyl-CoA elongase.