Iannone is a surname. Notable people with the surname include:
Andrea Iannone (born 1989), Italian professional motorcycle road racer
Bert Iannone (1917–1996), Canadian football player
Carol Iannone, conservative writer and literary critic
Claudio Iannone (born 1963), Argentine former cyclist
Dorothy Iannone, American-born visual artist
Filippo Iannone (born 1957), Roman Catholic church leader
Marvin P. Iannone, assistant chief of police of the Los Angeles Police Department and later the Chief of the Beverly Hills Police Department
Patrick Iannone, Italian professional ice hockey player
Tommaso Iannone (born 1990), Italian rugby union player
