Iacobescu ([jakoˈbesku]) is a Romanian surname:
Aimée Iacobescu (born 1946), Romanian actress
Antonia Iacobescu (born 1989), Romanian singer and model
D(umitru). Iacobescu (1893–1913), Romanian Symbolist poet
George Iacobescu (born 1945), Romanian-British businessman, the chief executive of Canary Wharf Group
Katharina Iacobescu, née Berthold (born 1986), German voice actress