Species Human Entrez 3710 | Human Mouse Ensembl ENSG00000096433 | |
Aliases ITPR3, IP3R, IP3R3, inositol 1,4,5-trisphosphate receptor type 3 External IDs MGI: 96624 HomoloGene: 1675 GeneCards: ITPR3 | ||
Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.
Function
ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.
References
ITPR3 Wikipedia(Text) CC BY-SA