Species Human Entrez 3674 | Human Mouse Ensembl ENSG00000005961 | |
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Aliases ITGA2B, BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93, integrin subunit alpha 2b External IDs MGI: 96601 HomoloGene: 37304 GeneCards: ITGA2B | ||
Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene.
ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Interactions
ITGA2B has been shown to interact with AUP1 and CLNS1A.
References
ITGA2B Wikipedia(Text) CC BY-SA