Suvarna Garge (Editor)

INHA

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Aliases
  
INHA

Human
  
Mouse

Ensembl
  
ENSG00000123999

Species
  
Human

Entrez
  
3623

INHA

External IDs
  
MGI: 96569 HomoloGene: 1652 GeneCards: INHA

Inhibin, alpha, also known as INHA, is a protein which in humans is encoded by the INHA gene.

Function

The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.

References

INHA Wikipedia