Suvarna Garge (Editor)

INHA

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Aliases
  
INHA

Human
  
Ensembl
  
ENSG00000123999

Species
  
Entrez
  
3623

INHA

External IDs
  
MGI: 96569 HomoloGene: 1652 GeneCards: INHA

Inhibin, alpha, also known as INHA, is a protein which in humans is encoded by the INHA gene.

Function

The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.

References

INHA Wikipedia


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