Species Human Entrez 84289 | Human Mouse Ensembl ENSG00000168395 | |
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Aliases ING5, p28inhibitor of growth family member 5 External IDs MGI: 1922816 HomoloGene: 90955 GeneCards: ING5 | ||
Inhibitor of growth protein 5 is a protein that in humans is encoded by the ING5 gene.
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.
Interactions
ING5 has been shown to interact with EP300 and P53.
References
ING5 Wikipedia(Text) CC BY-SA