Species Human Entrez 56300 | Human Mouse Ensembl ENSG00000136688 | |
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Aliases IL36G, interleukin 36, gamma, IL-1F9, IL-1H1, IL-1RP2, IL1E, IL1H1, IL1RP2, IL1F9 External IDs MGI: 2449929 HomoloGene: 49595 GeneCards: IL36G | ||
Interleukin-36 gamma also known as interleukin-1 family member 9 (IL1F9) is a protein that in humans is encoded by the IL36G gene.
Function
The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. IL36G expression has been linked to psoriasis lesions and has been used as a biomarker for differentiating between eczema and psoriasis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.