Entrez 27177 | Ensembl ENSG00000136696 | |
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Aliases IL36B, FIL1, FIL1-(ETA), FIL1H, FILI-(ETA), IL-1F8, IL-1H2, IL1-ETA, IL1F8, IL1H2, interleukin 36, beta External IDs MGI: 1916927 HomoloGene: 18278 GeneCards: IL36B | ||
Interleukin-36 beta also known as interleukin-1 family member 8 (IL1F8) is a protein that in humans is encoded by the IL36B gene.
Function
The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
References
IL36B Wikipedia(Text) CC BY-SA