Samiksha Jaiswal (Editor)

IGK@

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External IDs
  
GeneCards: IGK

Human
  
Mouse

Ensembl
  
n/a

Species
  
Human

Entrez
  
50802

Aliases
  
IGK, IGK@, immunoglobulin kappa locus

Immunoglobulin kappa locus, also known as IGK@, is a region on human chromosome 2 that contains genes for the kappa (κ) light chains of antibodies (or immunoglobulins).

In humans the κ chain is coded for by V (variable), J (joining) and C (constant) genes in this region. These genes undergo V(D)J recombination to generate a diverse repertoire of immunoglobulins.

Genes

The immunoglobulin kappa locus contains the following genes:

  • IGKC: immunoglobulin kappa constant
  • IGKJ@: immunoglobulin kappa joining group
  • IGKJ1, IGKJ2, IGKJ3, IGKJ4, IGKJ5
  • IGKV@: immunoglobulin kappa variable group
  • IGKV1-5, IGKV1-6, IGKV1-8, IGKV1-9, IGKV1-12, IGKV1-16, IGKV1-17, IGKV1-27, IGKV1-33
  • IGKV1D-8, IGKV1D-12, IGKV1D-13, IGKV1D-16, IGKV1D-17, IGKV1D-22, IGKV1D-27, IGKV1D-32, IGKV1D-33, IGKV1D-39, IGKV1D-43
  • IGKV2-24, IGKV2-28, IGKV2-30, IGKV2-40
  • IGKV2D-26, IGKV2D-28, IGKV2D-29, IGKV2D-30, IGKV2D-40
  • IGKV3-11, IGKV3-15, IGKV3-20
  • IGKV3D-7, IGKV3D-11, IGKV3D-20
  • IGKV4-1
  • IGKV5-2
  • and a number of non-functional and pseudogenes

    • References

    IGK@ Wikipedia
    (Text) CC BY-SA