Species Human Entrez 3400 | Human Mouse Ensembl ENSG00000172201 | |
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Aliases ID4, IDB4, bHLHb27, inhibitor of DNA binding 4, HLH protein External IDs MGI: 99414 HomoloGene: 1186 GeneCards: ID4 | ||
DNA-binding protein inhibitor ID-4 is a protein that in humans is encoded by the ID4 gene.
Function
Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative (antimorph) HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins.
References
ID4 Wikipedia(Text) CC BY-SA