Puneet Varma (Editor)

Hypoxia inducible factor asparagine dioxygenase

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EC number
  
1.14.11.30

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

MetaCyc
  
metabolic pathway

Hypoxia-inducible factor-asparagine dioxygenase (EC 1.14.11.30, HIF hydroxylase) is an enzyme with systematic name hypoxia-inducible factor-L-asparagine, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating). This enzyme catalyses the following chemical reaction

hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2 ⇌ hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2

Hypoxia-inducible factor-asparagine dioxygenase contains iron, and requires ascorbate.

References

Hypoxia-inducible factor-asparagine dioxygenase Wikipedia
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